[Rmannounce] DupMasker - A Tool for Annotating Primate Segmental Duplications

[Robert Hubley]

In collaboration with Evan Eichler and Zhaoshi Jiang at the University 
of Washington we developed the DupMasker program. DupMasker uses a 
library of non-redundant consensus sequences of human segmental 
duplications, wherein a majority of the ancestral origins have been 
determined based on comparisons to mammalian outgroup genomes. Using 
DupMasker, new human and non-human primate (NHP) sequences may be 
readily queried to provide details on the origin and degree of sequence 
identity of each duplicon. This program can be applied to delineate the 
order and orientation of duplicons within complex duplication blocks and 
used to characterize structural variation differences between sequenced 
human haplotypes. The paper describing this work can be found in the 
latest issue of Genome Research
( http://www.genome.org/cgi/content/abstract/gr.078477.108v1?ck=nck ) 
and the software may be
downloaded from: http://www.repeatmasker.org/DupMaskerDownload.html